Yes. You can submit multi-day leave requests that are within the same work week by entering the start/stop times and the appropriate range of dates.
Note that multiple weeks of leave should be entered as separate leave requests for each week (e.g. 11/30/2015 - 12/04/2015 and 12/07/2015 - 12/11/2015). A single request for leave from 11/30/2015 through 12/11/2015 would result in leave being requested for the weekend days in addition to the week days.