Job Posting: Chemist

Summary

This position is located in the Clinical Pharmacology Program (CPP), Office of the Clinical Director (OCD), Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), U.S. Department of Health and Human Services (HHS).

Duties

The incumbent serves as an analytical chemist supporting clinical pharmacology and translational drug-development research. The position develops, optimizes, validates, and applies quantitative bioanalytical methods to determine concentrations of drugs, metabolites, and related analytes in biological matrices, supporting pharmacokinetic and pharmacodynamic investigations and clinical study objectives. Develop, optimize, qualify, validate, transfer, and apply chromatographic and mass-spectrometric methods, particularly LC-MS/MS, for quantitative analysis of small-molecule drugs, metabolites, and selected peptides in biological specimens. Operate, maintain, and troubleshoot HPLC/UHPLC and tandem mass spectrometry systems; investigate sensitivity, selectivity, carryover, matrix effects, chromatographic interference, and analyte stability. Design and execute sample preparation procedures, including protein precipitation, liquid-liquid extraction, and solid-phase extraction; prepare calibrators, internal standards, blanks, and quality-control samples. Evaluate assay performance, including accuracy, precision, calibration range, lower limit of quantification, dilution integrity, selectivity, stability, and reproducibility; apply predefined acceptance criteria and document investigations. Acquire, process, critically review, and report quantitative data; contribute to pharmacokinetic data interpretation and coordination with clinical pharmacology investigators. Maintain traceable records, SOPs, method-validation protocols, sample-analysis reports, and quality documentation consistent with applicable FDA/EMA bioanalytical guidance, ICH M10, and laboratory quality practices. Coordinate specimen receipt, inventory, storage, transfers, and disposition; train laboratory personnel and communicate analytical findings to multidisciplinary study teams.

Who Can Apply