Tenure-Track/Tenure-Eligible Investigator, Laboratory of Host Immunity and Microbiome

This announcement has been amended to add the COVID-19 vaccine mandate to the conditions of employment.

This position is subject to the COVID-19 vaccine mandate as a condition of employment.

Job Summary

The National Institute of Allergy and Infectious Diseases (NIAID) — one of the largest Institutes of the National Institutes of Health (NIH), part of the U.S. Department of Health and Human Services (HHS)—is seeking to recruit outstanding, highly creative scientists to positions as tenure-track/tenure-eligible investigators (equivalent to assistant or associate professor level academic faculty) in its newly established Laboratory of Host Immunity and Microbiome (LHIM) in the Division of Intramural Research (DIR).

NIAID’s mission is to conduct and support basic and applied research to better understand, treat, and ultimately prevent infectious, immunologic, and allergic diseases. The vision of the new LHIM—led by Dr. Yasmine Belkaid—is to comprehensively examine the factors controlling immunity and inflammation, whether they are host intrinsic (e.g., tissue-specific or the consequence of tissue-tissue communication) or extrinsic (e.g., involve the microbiota, nutrition, or infection). Ongoing research within LHIM includes exploration of host-microbiota interactions, the long-term consequences of environmental stress on host immunity, and nutritional control of immunity. In pursuing its scientific goals, a major emphasis of LHIM will be on promoting collaborations between the laboratories within NIAID as well as with the larger National Institutes of Health (NIH) and extramural scientific communities. LHIM also has a strong emphasis on mentorship and fostering increased diversity in the next generation of scientific leaders. Additional information about LHIM staff, vision, and ongoing research activities is available online.

LHIM has been specifically organized to harness the unique resources available at NIH to conduct cutting-edge research. For example, it is home to the NIAID Microbiome Program that supports microbiome-related research through gnotobiotic, microbiology, and genomic core services. LHIM has also established a close partnership with the adjacent Laboratory of Immune System Biology to foster a rich intellectual and technological local environment. Some shared resources include: single-cell analysis, proteomics, genomics, and advanced imaging along with jointly held seminars and journal clubs and opportunities for mini-rotations to learn new methods and interact with other senior scientists in NIAID.

The ideal candidate will be an exceptional early or mid-stage investigator who shares LHIM’s vision for collaboration and mentorship and the application of transdisciplinary approaches to the exploration of host-microbe, tissue-tissue, or host-environment interactions. Areas of research focus could include but are not limited to: immunology (e.g., human immunology, immunometabolism, nutritional immunology), as well as microbiology (e.g., ecology, antimicrobial resistance), chemistry (e.g., microbiota-derived natural products), neuroscience (e.g., gut/brain axis), or genomics, with a particular interest in enhancing our understanding of host immunity. The incumbent will be expected to develop an innovative and highly collaborative research program that includes basic and/or translational studies. Applicants must have an M.D., Ph.D., M.D./Ph.D., or equivalent doctoral degree in a relevant field with postdoctoral experience as well as a strong publication record demonstrating potential for creative research.

This position is fully funded by the intramural research program of NIAID and includes support for salary, laboratory support personnel, equipment, space, supplies and services, and research animals/animal housing. Access is also provided to dedicated technical cores within NIAID in areas such as advanced imaging, flow cytometry, and genomics. Although sufficient support is provided for a strong research program, investigators and trainees are also eligible to apply for  additional funding from sources such as NIH internal grants (e.g., Bench-to-Bedside and Back Program), non-governmental research foundations, or partnerships with industry.

The intramural NIH community spans all field of biological research and is home to over 1,000 immunologists across numerous Institutes beyond NIAID. The incumbent will have access to state-of-the-art specialized cores in many of these other NIH intramural Institutes, the NIH Clinical Center (a premier research hospital on the main NIH campus), and the NIH Center for Human Immunology. In addition to postdoctoral fellowships, the intramural program offers numerous opportunities to host graduate students (Ph.D. or M.D./Ph.D.) via the NIH Oxford-Cambridge Scholars Program or through agreements with universities such as the NIH-Penn Immunology Graduate Partnership Program.

Required Qualifications

Vaccination Mandate

In accordance with Executive Order 14043, Federal employees are required to be fully vaccinated against COVID-19 regardless of the employee’s duty location or work arrangement (e.g., telework, remote work, etc.), subject to exceptions that may be required by law. If selected, you will be required to submit proof of vaccination by November 22, 2021 or before your entrance on duty if you are selected after the compliance date. Your HR Consultant will provide a list of documents acceptable as proof of vaccination and instructions for how to submit a request for a legally required exception, if needed, to comply with vaccination requirement.


Salary is commensurate with experience and accomplishments. A full civil-service package of benefits (including retirement; health, life, and long-term care insurance; and a Thrift Savings Plan) is available. Women and people from groups underrepresented in biomedical research are especially encouraged to apply. U.S. citizenship is not required — resident aliens or nonresident aliens eligible to obtain a valid employment-authorizing visa are encouraged to apply.

Expanded/Maximum Telework Posture

Due to COVID-19, the agency is currently in a maximum telework posture.  If selected, you may be expected to telework upon your appointment. As employees are permitted to return to the office, you may be required to report to the duty station listed on this announcement within 30 calendar days of receiving notice to do so, even if your home/temporary telework site is located outside the local commuting area. Your position may be eligible for workplace flexibilities which may include remote work or telework options, and/or flexible work scheduling. These flexibilities may be requested in accordance with the HHS Workplace Flexibilities policy.

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